Serum Gastrin Levels Are Associated With Prevalent Neuroendocrine Tumors in Autoimmune Metaplastic Atrophic Gastritis.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 39588964.
- Also identified by DOI 10.14309/ajg.0000000000003235 and PMC identifier 12136723.
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Abstract
Autoimmune metaplastic atrophic gastritis (AMAG) is a precancerous condition that predisposes to gastric neuroendocrine tumors (gNETs). There exist no methods to stratify patients with AMAG for gNET risk. We identified a cohort of patients with AMAG within a university health system using histopathologic and serologic criteria. We analyzed features predictive of prevalent gNET. We identified 181 patients with AMAG and 41 (22.7%) with prevalent gNET. Gastrin levels were elevated in gNET (1,859.8 vs 679.5 pg/mL, P < 0.001), and gastrin titers demonstrated good discrimination (c = 0.799, 95% CI 0.707-0.892) for gNET. Gastrin levels differ significantly between patients with AMAG with and without gNET.
Medical subject headings
- Gastrins
- Gastritis, Atrophic
- Neuroendocrine Tumors
- Stomach Neoplasms
- Autoimmune Diseases
- Precancerous Conditions