On the origin of mitosis-derived human embryo aneuploidy.
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- Record sourced from PubMed, PMID 39613785.
- Also identified by DOI 10.1038/s41467-024-54953-0 and PMC identifier 11607320.
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Abstract
Chromosome segregation errors are common in the early stages of human embryonic development. By examining the first mitotic divisions of human embryos using live cell imaging, three recent studies identify spindle architecture and positioning features that could provide insights into why early embryos are predisposed to chromosomal abnormalities.