The complete telomere-to-telomere sequence of a mouse genome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39636971.
- Also identified by DOI 10.1126/science.adq8191.
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Abstract
The current reference genome of <i>Mus musculus</i>, GRCm39, has major gaps in both euchromatic and heterochromatic regions associated with repetitive sequences. In this work, we have sequenced and assembled the telomere-to-telomere genome of mouse haploid embryonic stem cells. The results reveal more than 7.7% of previously uncovered sequences of the mouse genome, including ribosomal DNA arrays and pericentromeric and subtelomeric regions, as well as an additional 140 genes predicted to be protein-coding. This study helps to address knowledge gaps in the mouse genome.
Medical subject headings
- Mice
- Genome
- Telomere
- Mice, Inbred C57BL