From brain to blood and back again: Linking chronic stress, myelopoiesis, and depression.
editorial · Level V
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- Record sourced from PubMed, PMID 39642860.
- Also identified by DOI 10.1016/j.stem.2024.11.012.
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Abstract
In this issue of Cell Stem Cell, Mou et al. identified a brain-bone marrow axis reinforcing myelopoiesis and neuroinflammation during psychological stress, culminating in depression. The identification of this pathway provides insights into hematopoietic stem cell homeostasis and regulatory neuronal function with potentially significant implications for the treatment of stress-related disorders.
Medical subject headings
- Myelopoiesis
- Depression
- Brain
- Stress, Psychological