Randomized trials: When scientific rigor meets field reality.

Hannoun-Levi, J M; Savignoni, A; Lemonnier, J; Kirova, Youlia · Radiother Oncol · 2025

review · Level V

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Abstract

Results from prospective randomized trial results are required to provide practice-changing level-1 evidence. However, if such a trial is not feasible, we should not accept that consequently practice could not change. We discuss hereby a pragmatically approach based on methodological alternatives.

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