Trojan Horse Bioheterojunction Empowers Adhesive Hydrogel with Robust Antibacterial Activity and Sensing Capacity for Infected Cutaneous Regeneration.

Abstract

Strategic integration of adhesive hydrogels with phototherapy-based antibacterial properties has been extensively leveraged in infected tissue repair. Nevertheless, the interference of bacterial heat shock proteins and antioxidant defense systems attenuates the bactericidal potency of phototherapy. To address this imposing predicament, a Trojan horse bioheterojunction (Th-bioHJ) incorporating liquid metal and copper sulfide is devised to confer an adhesive hydrogel with multimodal and comprehensive antibacterial properties for remedying infectious wounds. Th-bioHJ generates phototherapeutic effects and interrupts the electron transport chain with the Trojan horse strategy, achieving rapid and robust sterilization. Additionally, Th-bioHJ promotes cell migration and angiogenesis. <i>In vivo</i> studies elucidate the remarkable efficacy of Th-bioHJ hydrogel in rapidly eradicating bacteria, promoting angiogenesis and boosting infectious cutaneous regeneration. Meanwhile, the Th-bioHJ hydrogel demonstrates exceptional biointerface adhesion and sensing capabilities for real-time motion monitoring. This study provides groundbreaking insights into the innovative application of an adhesive hydrogel in the management of infected wounds.