ProHap enables human proteomic database generation accounting for population diversity.
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- Record sourced from PubMed, PMID 39653819.
- Also identified by DOI 10.1038/s41592-024-02506-0.
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Abstract
Amid the advances in genomics, the availability of large reference panels of human haplotypes is key to account for human diversity within and across populations. However, mass spectrometry-based proteomics does not benefit from this information. To address this gap, we introduce ProHap, a Python-based tool that constructs protein sequence databases from phased genotypes of reference panels. ProHap enables researchers to account for haplotype diversity in proteomic searches.
Medical subject headings
- Proteomics
- Databases, Protein
- Software
- Genetic Variation