Facile construction of distal and diversified tertiary and quaternary stereocenters.
basic_science · Level V
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- Record sourced from PubMed, PMID 39665763.
- Also identified by DOI 10.1073/pnas.2408541121 and PMC identifier 11665887.
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Abstract
Exploration of novel chiral pharmaceutical candidates is motivation to immersive efforts among synthetic chemists. Achieving skeletal construction and chiral diversity in a highly efficient manner is a momentous goal in the chemical society. Unfortunately, current methods for chiral induction focus primarily on a specific site. Herein, we realized the asymmetric chain-walking arylation of alkenyl alcohols for the construction of multisite tertiary and quaternary stereocenters in high yields and enantioselectivity. This new operation-friendly strategy carries substantial potential for future industrialization.