Decline of Antibodies to Major Viral and Bacterial Respiratory Pathogens During the COVID-19 Pandemic.

Lorenz, Natalie; James, Alex; Van Rooyen, Tiaan; Paterson, Aimee; Ramiah, Ciara; Carlton, Lauren H; Sharma, Prachi; Baker, Michael G et al. · J Infect Dis · 2025

prospective_cohort · Level II

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Abstract

Surges in infections caused by respiratory pathogens have been documented in multiple settings after relaxation of pandemic restrictions. Antibodies to major antigens from respiratory syncytial virus and group A Streptococcus waned significantly in a longitudinal adult cohort throughout the pandemic. This waning may have contributed to the pathogen-surges that followed.

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