Precocious Puberty in Children with Neurofibromatosis Type 1.

Katz, Julia; Ratnam, Sarayu; Listernick, Robert H; Habiby, Reema L; Gutmann, David H · J Pediatr · 2025

case_series · Level IV

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Abstract

This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the development of CPP.

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