Breathing orchestrates synchronization of sleep oscillations in the human hippocampus.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39680758.
- Also identified by DOI 10.1073/pnas.2405395121 and PMC identifier 11670218.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory-driven oscillation in the human hippocampus that couples with cardinal sleep oscillations. Further, breathing promotes nesting of ripples in slow oscillations, together suggesting that respiration acts as an intrinsic rhythm to coordinate synchronization of sleep oscillations, providing a unique framework to characterize sleep-related respiratory and memory processes.
Medical subject headings
- Hippocampus
- Sleep
- Respiration