Functionalized Bone Implant Inspired by Lattice Defense Strategy: Grid Management, Precise and Effective Multiple-Prevention of Osteomyelitis Recurrence and Promote Bone Regeneration.

Abstract

Osteomyelitis with a high recurrence rate. Timely-prevention can avoid severe consequence and death. However, conventional drug response-release has the disadvantages of unnecessary release and waste, causing ineffective prevention. Inspired by "Lattice-defense technology", gridding lesion areas and constructing a "Triggered-precise response-release system" may be an effective multiple-prevention method. Here, a new strict pH-triggered response drug controlled-release mechanism was proposed innovatively to construct a "Triggered-precise response-release system" and achieve multiple-effective prevention. PO₄ ^3--Ce³⁺ strict pH responsive release system is prepared through simultaneous hydration reaction of solution-polymerization and compounded in bone-implant. The dispersed system only targets micro-interface contact areas, achieving gridded management of the lesion site. In a normal environment, Ce³⁺ is captured by PO₄ ^3- and kept electrostatic-attraction balance, ensuring the zero-concentration Ce³⁺ release continuously. Once osteomyelitis recurs and pH decrease, H+ at the interface will combine with PO₄ ^3- under electrostatic drive and disrupt potential balance, achieving the release of Ce³⁺ only when the infection recurs. In vivo experiments was confirmed effective prevention and excellent promote bone regeneration. The adoption of "Lattice defense technology" has achieved accuracy spatiotemporal of drug delivery. Even if other lesion sites unfortunately recur again, effective-prevention can be guaranteed. Bone-implant show great potential in preventing osteomyelitis.