Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair.

Cong, Ting; Morse, Kyle W; Sosa, Branden R; Lane, Joseph M; Rodeo, Scott A; Greenblatt, Matthew B · J Bone Joint Surg Am · 2025

review · Level V

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Abstract

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

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