Congenital Toxoplasmosis: Fewer Clinical Signs at 3 Years of Age Over the Last 15 Years but Stable Risk of Materno-fetal Transmission.

Wallon, Martine; Ksiazek, Elea; Journé, Antoine; Dupont, Damien; Menotti, Jean; Peyron, François; Binquet, Christine · Clin Infect Dis · 2025

retrospective_cohort · Level III

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Abstract

The risk and severity of congenital toxoplasmosis were estimated using data from 2455 consecutive mother-child pairs. Clinical signs at 3 years were halved in the 177 children born since 2009 compared with 1996-2008 (odds ratio = .49; 95% CI: .28-.85). Materno-fetal transmission rates remained stable from 1992 to 2021.

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