Derivation and Validation of an Electronic Health Record Penicillin Allergy De-Labeling Prevalence Measure.

Blumenthal, Kimberly G; Jiang, Bohang; King, Andrew J; Mann, Jushin T; Zhang, Yuqing; Wurcel, Alysse G · Clin Infect Dis · 2025

cross_sectional · Level IV

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Abstract

With no standard method to capture penicillin allergy de-labeling prevalence across populations, we developed and validated a simple penicillin allergy de-labeling prevalence measure from electronic health records that achieved perfect sensitivity (100.0%), high specificity (99.4%), and strong agreement with a comprehensive algorithm that included free-text manual review (kappa = .997).

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