Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39710201.
- Also identified by DOI 10.1016/j.wneu.2024.123595 and PMC identifier 12094189.
- Licence recorded as CC BY-NC-ND.
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Abstract
The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood-brain and blood-tumor barrier in a safe and effective manner.
Medical subject headings
- Oncolytic Virotherapy
- Glioma
- Brain Neoplasms
- Oncolytic Viruses
- Simplexvirus