Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxycycline Postexposure Prophylaxis-Eligible Population.

Mittelstaedt, Rachel; Kanjilal, Sanjat; Helekal, David; Robbins, Gregory K; Grad, Yonatan H · J Infect Dis · 2025

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Abstract

Among doxycycline postexposure prophylaxis (doxy-PEP)-eligible men, Staphylococcus aureus tetracycline nonsusceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for multidrug-resistant S aureus, underscoring the importance of surveillance.

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