The monogenic landscape of human infectious diseases.
Where this comes from
- Record sourced from PubMed, PMID 39724971.
- Also identified by DOI 10.1016/j.jaci.2024.12.1078 and PMC identifier 11875930.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The spectrum of known monogenic inborn errors of immunity is growing, with certain disorders underlying a specific and narrow range of infectious diseases. These disorders reveal the core mechanisms by which these infections occur in various settings, including inherited and acquired immunodeficiencies, thereby delineating the essential mechanisms of protective immunity to the corresponding pathogens. These findings also have medical implications, facilitating diagnosis and improving the management of individuals at risk of disease.
Medical subject headings
- Communicable Diseases
- Immunologic Deficiency Syndromes