Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39747026.
- Also identified by DOI 10.1038/s41467-024-55406-4 and PMC identifier 11696175.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.
Medical subject headings
- Hippocampus
- Neurons
- Action Potentials
- Memory
- Models, Neurological