Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39747826.
- Also identified by DOI 10.1038/s41467-024-55379-4 and PMC identifier 11697022.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Extracellular vesicles (EVs) are associated with intercellular communications, immune responses, viral pathogenicity, cardiovascular diseases, neurological disorders, and cancer progression. EVs deliver proteins, metabolites, and nucleic acids into recipient cells to effectively alter their physiological and biological response. During their transportation from the donor to the recipient cell EVs face differential ionic concentrations, which can be detrimental to their integrity and impact their cargo content. EVs are known to possess ion channels and transporters in their membrane but neither the function nor the role of these channels in EVs is known. In this study, we discover a functional calcium-activated large-conductance potassium channel (BK<sub>Ca</sub>) in the membrane of EVs. Furthermore, we establish that BK<sub>Ca</sub> is essential for the structural and functional integrity of EVs. Together, these findings establish the critical role of ion channels such as BK<sub>Ca</sub> in functioning as gatekeepers and maintaining EV-mediated signaling.
Medical subject headings
- Extracellular Vesicles