Comprehensive characterization of the transcriptional landscape in Alzheimer's disease (AD) brains.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39752483.
- Also identified by DOI 10.1126/sciadv.adn1927 and PMC identifier 11698078.
- Licence recorded as CC BY-NC.
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Abstract
Alzheimer's disease (AD) is the leading dementia among the elderly with complex origins. Despite extensive investigation into the AD-associated protein-coding genes, the involvement of noncoding RNAs (ncRNAs) and posttranscriptional modification (PTM) in AD pathogenesis remains unclear. Here, we comprehensively characterized the landscape of ncRNAs and PTM events in 1460 samples across six brain regions sourced from the Mount Sinai/JJ Peters VA Medical Center Brain Bank Study and Mayo cohorts, encompassing 33,321 long ncRNAs, 92,897 enhancer RNAs, 53,763 alternative polyadenylation events, and 900,221 A-to-I RNA editing events. We additionally identified 25,351 aberrantly expressed ncRNAs and altered PTM events associated with AD traits and further identified the corresponding protein-coding genes to construct regulatory networks. Furthermore, we developed a user-friendly data portal, ADatlas, facilitating users in exploring our results. Our study aims to establish a comprehensive data platform for ncRNAs and PTMs in AD to advance related research.
Medical subject headings
- Alzheimer Disease
- Brain
- Gene Regulatory Networks