Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39752561.
- Also identified by DOI 10.2337/db24-0553 and PMC identifier 11926280.
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Abstract
Renin-angiotensin system (RAS) activation plays an important role in the progression of diabetic kidney disease (DKD). However, systemic RAS blockade alone is insufficient to reverse DKD progression. We hypothesized that intrarenal renin-angiotensin system (iRAS) activation plays a crucial role in the progression of DKD. We sought to elucidate the role of the iRAS in DKD progression. Selective deletion of angiotensinogen in renal tubules ameliorated the pathological features of DKD. Our study indicates that iRAS inactivation may be a potential approach for preventing DKD disease severity and its progression.
Medical subject headings
- Angiotensinogen
- Diabetic Nephropathies
- Diabetes Mellitus, Type 1
- Sodium-Glucose Transporter 2
- Kidney Tubules
- Diabetes Mellitus, Experimental