Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39753543.
- Also identified by DOI 10.1038/s41467-024-55592-1 and PMC identifier 11698737.
- Licence recorded as CC BY-NC-ND.
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Abstract
This study presents a copper-catalyzed, substrate-controlled regio- and enantioselective intermolecular hydrosilylation method capable of accommodating a broad scope of alkenes and prochiral silanes. The approach offers an efficient and versatile pathway to generate enantioenriched linear and branched alkyl-substituted Si-stereogenic silanes. Key features of this reaction include mild reaction conditions, simple catalytic systems, compatibility with diverse substrates, high yields and enantioselectivities.