Intestinal mucosal mitochondrial oxidative phosphorylation worsens with cirrhosis progression and is ameliorated with fecal microbiota transplantation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39773539.
- Also identified by DOI 10.1172/jci.insight.186649 and PMC identifier 11949008.
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Abstract
Cirrhosis, the end-stage of liver disease, progresses through altered gut-liver axis and microbial change. Here we show that intestinal mucosal mitochondrial oxidative phosphorylation, which affects intestinal barrier worsens with cirrhosis progression. This is ameliorated with fecal microbiota transplantation.
Medical subject headings
- Fecal Microbiota Transplantation
- Oxidative Phosphorylation
- Liver Cirrhosis
- Intestinal Mucosa
- Mitochondria