Helminth Infection Induces Innate Immune Priming in Plasmacytoid Dendritic Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39776172.
- Also identified by DOI 10.1093/infdis/jiaf009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Heligmosomoides polygyrus coinfection is reported to have protective antiviral effects against pulmonary viral infections. To investigate a potential underlying mechanism, we infected C57BL/6 mice with H. polygyrus larvae for 2 weeks. Bone marrow (BM)-derived plasmacytoid dendritic cells (pDCs) were generated and stimulated with Toll-like receptor agonists. We found increased expression of type 1 interferon genes (Ifnα1, Ifnα4, Ifnβ1, Mx1, Isg15), increased TNF, IL-6, IL-10 secretion, and higher expression of antigen presentation markers in BM-derived-pDCs from infected compared to naive control mice. Our findings may partly explain the mechanism of the antiviral protection previously reported in acute helminth infections.
Medical subject headings
- Dendritic Cells
- Nematospiroides dubius
- Immunity, Innate
- Strongylida Infections