CCL17 Influences Borrelia burgdorferi Infection in the Heart.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39777514.
- Also identified by DOI 10.1093/infdis/jiaf011 and PMC identifier 12308671.
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Abstract
Lyme disease, caused by Borrelia burgdorferi, is transmitted to humans by Ixodes ticks. CCL17 is a potent chemokine that plays important roles in diverse illnesses, including autoimmune and infectious diseases. CCL17 knockout mice, infected with B. burgdorferi, had a reduced pathogen load in the heart compared to control animals. Mice lacking CCL17 also showed signs of immune alteration upon B. burgdorferi infection, including diverse serum levels of proinflammatory cytokines and less monocytes and macrophages infiltration. CCL17 also interacts directly with B. burgdorferi, the first demonstration that this chemokine has an affinity for a vector-borne pathogen.
Medical subject headings
- Lyme Disease
- Borrelia burgdorferi
- Chemokine CCL17
- Heart