Inflammation in Cerebral Amyloid Angiopathy-Related Transient Focal Neurological Episodes.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39777804.
- Also identified by DOI 10.1002/ana.27164 and PMC identifier 11831886.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Transient focal neurological episodes (TFNE), often associated with convexity subarachnoid hemorrhage (cSAH), are common in cerebral amyloid angiopathy (CAA), but their pathophysiology remains incompletely understood. In six patients with unremitting TFNE, using high-resolution post-contrast magnetic resonance imaging and vessel wall imaging (VWI), we found various combinations of transient leptomeningeal, parenchymal and vessel wall enhancement; in 5 of 6 the enhancement included regions corresponding anatomically to symptoms. Three patients had resolution of TFNE and enhancement (2 with corticosteroid treatment, 1 without). Our observations suggest that inflammation might contribute to the pathophysiology of CAA-related TFNE and cSAH, with potential wider relevance for the associated high risks of recurrent ICH in CAA more generally. ANN NEUROL 2025;97:475-482.
Medical subject headings
- Cerebral Amyloid Angiopathy
- Subarachnoid Hemorrhage
- Inflammation