Advancing de novo lipogenesis: Genetic and metabolic insights.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39778518.
- Also identified by DOI 10.1016/j.cmet.2024.12.001 and PMC identifier 13050314.
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Abstract
De novo lipogenesis (DNL) is the process whereby cells synthesize fatty acids from acetyl-CoA, contributing to steatosis in fatty liver disease. Two new studies, using genetic mouse models, metabolomics, and pharmacology, identified alternative pathways in DNL and unexpected physiological effects when targeting key enzymes in this pathway.
Medical subject headings
- Lipogenesis