JMJD8 Regulates Adipocyte Hypertrophy Through the Interaction With Perilipin 2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39787420.
- Also identified by DOI 10.2337/db23-0883 and PMC identifier 11926275.
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Abstract
New research builds on previous findings that JMJD8 mediates insulin resistance by promoting adipocyte hypertrophy. We identified PLIN2 as a binding partner of JMJD8 using proteomics approaches. This study reveals a physical interaction between JMJD8 and PLIN2, which plays a crucial role in driving adipocyte hypertrophy and insulin resistance. JMJD8 suppresses fasting-induced lipophagy and reduces energy production by inhibiting PLIN2 phosphorylation. These findings highlight the importance of JMJD8 and PLIN2 in regulating lipid droplet homeostasis and suggest a potential mechanism for controlling fat mobilization during energy deprivation.
Medical subject headings
- Adipocytes
- Perilipin-2
- Jumonji Domain-Containing Histone Demethylases
- Perilipins