Time-Resolved Effects of Short-term Overfeeding on Energy Balance in Mice.

Ranea-Robles, Pablo; Lund, Camilla; Svendsen, Charlotte; Gil, Cláudia; Lund, Jens; Kleinert, Maximilian; Clemmensen, Christoffer · Diabetes · 2025

basic_science · Level V

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Abstract

Intragastric overfeeding reveals insights into the homeostatic recovery from experimental weight gain. Protection against short-term, overfeeding-induced weight gain primarily involves a profound reduction in food intake and possibly an adaptive increase in energy expenditure. UCP1-mediated thermogenesis is not essential for homeostatic protection against short-term, overfeeding-induced weight gain.

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