Rnd3 Ameliorates Diabetic Cardiac Microvascular Injury via Facilitating Trim40-Mediated Rock1 Ubiquitination.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39792251.
- Also identified by DOI 10.2337/db24-0543.
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Abstract
Impaired cardiac microvascular function is a significant contributor to diabetic cardiomyopathy. Rnd3 expression is notably downregulated in cardiac microvascular endothelial cells under diabetic conditions. Rnd3 overexpression mitigates diabetic myocardial microvascular injury and improves cardiac function through the Rock1/myosin light chain signaling pathway. Rnd3 facilitates the recruitment and interaction with Trim40 to promote Rock1 ubiquitination, thereby preserving endothelial barrier integrity in the diabetic heart.
Medical subject headings
- rho-Associated Kinases
- Diabetic Cardiomyopathies
- Ubiquitin-Protein Ligases
- rho GTP-Binding Proteins
- Tripartite Motif Proteins
- Microvessels