TP53 genetic heterogeneity in recurrent or second primary head and neck squamous cell carcinoma.
Where this comes from
- Record sourced from PubMed, PMID 39800270.
- Also identified by DOI 10.1016/j.radonc.2025.110714.
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Abstract
Head and neck squamous cell carcinomas (HNSCC) frequently recur, and patients often develop second primary tumors. Their distinction is clinically challenging. TP53 mutational heterogeneity may indicate novel molecular events rather than resistant clones' expansion or persistent disease. Surveillance and therapeutic strategies should be adjusted, especially in the case of a second primary arising in an already irradiated field.
Medical subject headings
- Carcinoma, Squamous Cell
- Genes, p53
- Genetic Heterogeneity
- Head and Neck Neoplasms
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary
- Tumor Suppressor Protein p53