Structure of transmembrane AMPA receptor regulatory protein subunit γ2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39809794.
- Also identified by DOI 10.1038/s41467-025-56027-1 and PMC identifier 11733119.
- Licence recorded as CC BY-NC-ND.
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Abstract
Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. With cryo-electron microscopy (cryo-EM) we reconstruct the 36 kDa TARP subunit γ2 to 2.3 Å, which points to structural diversity among TARPs. Our data reveals critical motifs that distinguish TARPs from claudins and define how sequence variations within TARPs differentiate subfamilies and their regulation of AMPARs.
Medical subject headings
- Receptors, AMPA
- Calcium Channels