Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis.
basic_science · Level V
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- Record sourced from PubMed, PMID 39817449.
- Also identified by DOI 10.1172/JCI188538 and PMC identifier 11735092.
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Abstract
How are autoreactive T cells induced and regulated in patients with autoimmune disease? This question lies at the core of understanding autoimmune disease pathologies, yet it has remained elusive due to host variability and the complexity of the immune system. In this issue of the JCI, Kramer and colleagues used autoimmune hepatitis (AIH) as a model to explore the maintenance of autoreactive CD4+ T cells specific to O-phosphoseryl-tRNA:selenocysteine tRNA synthase (SepSecS). The findings provide insight into the interaction between T cells and B cells in AIH pathogenesis that may reflect a shared mechanism among other autoimmune diseases.
Medical subject headings
- Hepatitis, Autoimmune
- B-Lymphocytes
- CD4-Positive T-Lymphocytes