Evolution of interorganismal strigolactone biosynthesis in seed plants.
basic_science · Level V
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- Record sourced from PubMed, PMID 39818909.
- Also identified by DOI 10.1126/science.adp0779.
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Abstract
Strigolactones (SLs) are methylbutenolide molecules derived from β-carotene through an intermediate carlactonoic acid (CLA). Canonical SLs act as signals to microbes and plants, whereas noncanonical SLs are primarily plant hormones. The cytochrome P450 CYP722C catalyzes a critical step, converting CLA to canonical SLs in most angiosperms. Using synthetic biology, we investigated the function of <i>CYP722A</i>, an evolutionary predecessor of <i>CYP722C</i>. CYP722A converts CLA into 16-hydroxy-CLA (16-OH-CLA), a noncanonical SL detected exclusively in the shoots of various flowering plants. 16-OH-CLA application restores control of shoot branching to SL-deficient mutants in <i>Arabidopsis thaliana</i> and is perceived by the SL signaling pathway. We hypothesize that biosynthesis of 16-OH-CLA by CYP722A was a metabolic stepping stone in the evolution of canonical SLs that mediate rhizospheric signaling in many flowering plants.
Medical subject headings
- Arabidopsis
- Cytochrome P-450 Enzyme System
- Evolution, Molecular
- Lactones
- Plant Growth Regulators
- Seeds
- Heterocyclic Compounds, 3-Ring
- Aquilegia