Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention.

Close, Elizabeth; Jones, Alexander; Noggle, William · J Am Board Fam Med · 2025

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Abstract

Consider prescribing doxycycline as prophylaxis for bacterial sexually transmitted infections (STIs) in certain clinical scenarios. New data suggests that a one-time dose of 200 mg doxycycline taken within 72 hours of an unprotected sexual encounter may reduce transmission of syphilis, gonorrhea and chlamydia by a combined two thirds in a high-risk population.

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