Mannose: A game-changer for T cell immunotherapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39826542.
- Also identified by DOI 10.1016/j.cmet.2024.12.014.
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Abstract
Metabolism influences the behavior of various immune cell types. In a recent Cancer Cell study, Qiu et al. revealed mannose metabolism as a prominent metabolic feature of tumor precursor exhausted T cells (Tpex) that is crucial for maintaining T cell stemness. Their work uncovers a novel metabolic mechanism that decouples T cell proliferation from differentiation, providing valuable insights into how metabolic modulation can be used to generate "better" T cells during the manufacturing process.
Medical subject headings
- Mannose
- T-Lymphocytes
- Immunotherapy
- Neoplasms