Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39835775.
- Also identified by DOI 10.7554/eLife.100767 and PMC identifier 11750132.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Mutations in Sonic Hedgehog (SHH) signaling pathway genes, for example, <i>Suppressor of Fused</i> (SUFU), drive granule neuron precursors (GNP) to form medulloblastomas (MB<sup>SHH</sup>). However, how different molecular lesions in the Shh pathway drive transformation is frequently unclear, and <i>SUFU</i> mutations in the cerebellum seem distinct. In this study, we show that fibroblast growth factor 5 (FGF5) signaling is integral for many infantile MB<sup>SHH</sup> cases and that <i>FGF5</i> expression is uniquely upregulated in infantile MB<sup>SHH</sup> tumors. Similarly, mice lacking SUFU (Sufu-cKO) ectopically express <i>Fgf5</i> specifically along the secondary fissure where GNPs harbor preneoplastic lesions and show that FGFR signaling is also ectopically activated in this region. Treatment with an FGFR antagonist rescues the severe GNP hyperplasia and restores cerebellar architecture. Thus, direct inhibition of FGF signaling may be a promising and novel therapeutic candidate for infantile MB<sup>SHH</sup>.
Medical subject headings
- Medulloblastoma
- Signal Transduction
- Hedgehog Proteins
- Fibroblast Growth Factors
- Cerebellar Neoplasms
- Neural Stem Cells