Approach to the Patient: Diagnostic Challenges in the Workup for Polycystic Ovary Syndrome.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39836632.
- Also identified by DOI 10.1210/clinem/dgae910 and PMC identifier 12187463.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Polycystic ovary syndrome (PCOS) affects 10% to 13% of women globally. It is a condition with metabolic, reproductive, and psychological features, with health impacts across the lifespan. The etiology of PCOS is complex, with an interplay of several factors, including genetic and epigenetic susceptibility, androgen exposure in early life and adiposity-related dysfunction leading to hypothalamic-ovarian disturbance. Diagnosis is recommended based on the International PCOS Guideline criteria, with diagnosis confirmed in adults when 2 of out the following 3 criteria are met: (i) hyperandrogenism (clinical or biochemical); (ii) irregular cycles; and (iii) polycystic ovary morphology or elevated anti-Müllerian hormone (AMH) levels. With its clinical heterogeneity, distinct phenotypes, variation across the lifespan and ethnic variation, PCOS diagnosis can present significant diagnostic challenges to clinicians.
Medical subject headings
- Polycystic Ovary Syndrome