False-Positive FAPI Expression in Benign Breast Adenosis.

Gunasekaran, Vinisha; Subrhamanian, Avanthiga; Ambalavanan, Nivetha; Singh, Harmandeep; Kumar, Rajender; Mittal, Bhagwant Rai; Shukla, Jaya; Walia, Rama et al. · Clin Nucl Med · 2025

case_report · Level V

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Abstract

Breast adenosis is a benign glandular proliferative disorder. Due to its imaging similarities with other malignant breast lesions, differentiating adenosis from other invasive carcinomas of the breast poses a diagnostic challenge. Fibroblast activation protein inhibitor (FAPI) expression is observed in various benign and malignant lesions, increasing the risk of false-positive results. We present a case of FAPI-avid benign breast adenosis in a patient with adrenal adenocarcinoma in 68 Ga-FAPI-46 PET/CT.

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