The mitochondrial choline transporter, SLC25A48, regulates urine and blood choline levels in humans.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39848743.
- Also identified by DOI 10.1016/j.kint.2024.11.014.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Choline is an essential nutrient for the biosynthesis of phospholipids and neurotransmitters and controls several physiological functions in mammals. It is metabolized in the organelles within cells, including mitochondria. However, its subcellular distribution and mode of mitochondrial transport remain poorly understood. Patil et al. identified SLC25A48 as a mitochondrial choline transporter, and its loss-of-function mutations were associated with elevated urine and plasma choline levels in humans.
Medical subject headings
- Choline
- Mitochondria
- Membrane Transport Proteins