Homeobox C4 Transcription Factor Promotes Adipose Tissue Thermogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39854216.
- Also identified by DOI 10.2337/db24-0675 and PMC identifier 11926272.
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Abstract
Homeobox C4 (HOXC4) links metabolic pathways and correlates inversely with mouse body weight and positively with Ucp1 expression in mouse adipose tissue. Gain- and loss-of-function experiments in mice demonstrated HOXC4's essential role in promoting adipose thermogenesis and providing metabolic benefits. HOXC4 interacts with the nuclear receptor coactivator 1 cofactor via its hexapeptide motif to activate Ucp1 transcription, revealing a novel mechanism of thermogenic gene regulation.
Medical subject headings
- Thermogenesis
- Homeodomain Proteins
- Adipose Tissue
- Transcription Factors