Extracellular Vesicle-Associated miR-ERIA Exerts the Antiangiogenic Effect of Macrophages in Diabetic Wound Healing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39854218.
- Also identified by DOI 10.2337/db24-0701 and PMC identifier 11926273.
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Abstract
An understanding of cell interactions is needed to identify therapeutic targets for diabetic cutaneous ulcers. We explored extracellular vesicles after treatment with advanced glycation end products (AGEs-EVs) derived from macrophages that can suppress diabetic cutaneous wound healing. We found that a novel miRNA enriched in AGEs-EVs (miR-ERIA) suppresses the migration and tube formation of vascular endothelial cells by targeting helicase with zinc finger 2. miR-ERIA offers a potential therapeutic target for diabetic cutaneous ulcers.
Medical subject headings
- Extracellular Vesicles
- Wound Healing
- MicroRNAs
- Macrophages