Rings of death: How NINJ1 executes plasma membrane rupture.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39855152.
- Also identified by DOI 10.1016/j.cell.2024.12.030 and PMC identifier 12955851.
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Abstract
Plasma membrane rupture during lytic cell death was previously believed to occur through passive osmosis that burst open the membrane. Recent publications, including one in this issue of Cell, suggest that plasma membrane rupture is an active process mediated by ninjurin-1 (NINJ1) oligomers that dissolve membranes and/or assemble large pores.
Medical subject headings
- Cell Membrane
- Cell Adhesion Molecules, Neuronal