Large language model-augmented learning for auto-delineation of treatment targets in head-and-neck cancer radiotherapy.

Abstract

Radiation therapy (RT) is highly effective, but its success depends on accurate, manual target delineation, which is time-consuming, labor-intensive, and prone to variability. Despite AI advancements in auto-contouring normal tissues, accurate RT target volume delineation remains challenging. This study presents Radformer, a novel visual language model that integrates text-rich clinical data with medical imaging for accurate automated RT target volume delineation. We developed Radformer, an innovative network that utilizes a hierarchical vision transformer as its backbone and integrates large language models (LLMs) to extract and embed clinical data in text-rich form. The model features a novel visual language attention module (VLAM) to combine visual and linguistic features, enabling language-aware visual encoding (LAVE). The Radformer was evaluated on a dataset of 2985 patients with head-and-neck cancer who underwent RT. Quantitative evaluations were performed utilizing metrics such as the Dice similarity coefficient (DSC), intersection over union (IOU), and 95th percentile Hausdorff distance (HD95). The Radformer demonstrated superior performance in segmenting RT target volumes compared to state-of-the-art models. On the head-and-neck cancer dataset, Radformer achieved a mean DSC of 0.76 ± 0.09 versus 0.66 ± 0.09, a mean IOU of 0.69 ± 0.08 versus 0.59 ± 0.07, and a mean HD95 of 7.82 ± 6.87 mm versus 14.28 ± 6.85 mm for gross tumor volume delineation, compared to the baseline 3D-UNETR. The Radformer model offers a clinically optimal means of RT target auto-delineation by integrating both imaging and clinical data through a visual language model. This approach improves the accuracy of RT target volume delineation, facilitating broader AI-assisted automation in RT treatment planning.