LINE-1 Retrotransposons as Cell-free DNA Biomarkers for Multicancer Early Detection.
Where this comes from
- Record sourced from PubMed, PMID 39879112.
- Also identified by DOI 10.1158/1078-0432.CCR-24-4051 and PMC identifier 11961311.
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Abstract
LINE-1 retrotransposons, comprising 17% of the genome, drive cancer instability through hypomethylation. The Detection of long Interspersed nuclear element Altered Methylation ON plasma DNA (DIAMOND) assay, targeting LINE-1 hypomethylation with bisulfite sequencing of cell-free DNA, achieved AUCs of 88% to 100% across six cancer types, surpassing mutation-based diagnostics and suggesting utility in early cancer detection and management. See related article by Michel et al., p. 1275.
Medical subject headings
- Long Interspersed Nucleotide Elements
- Biomarkers, Tumor
- Neoplasms
- Early Detection of Cancer
- Cell-Free Nucleic Acids