Anti-SARS-CoV-2 Immunoglobulin G Antibody Titers in Contemporary Lots of Intravenous Immunoglobulin and Fresh Frozen Plasma Compared With COVID-19 Convalescent Plasma.

Smith, Ethan A; Javier, Ginny M; Multani, Ashrit; Beaird, Omer Eugene; Gaynor, Pryce; Yanagimoto-Ogawa, Lauren; Schaenman, Joanna; Allyn, Paul et al. · Clin Infect Dis · 2025

cross_sectional · Level IV

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Abstract

Given declining coronavirus disease 2019 convalescent plasma (CCP) collection and increasing scarcity, we compared anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody titers between CCP, intravenous immunoglobulin, and fresh frozen plasma. Herein, we report comparative anti-SARS-CoV-2 IgG antibody titers between 5 lots of each blood product, using the DiaSorin Liaison SARS-CoV-2 TrimericS IgG assay.

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