Blood pressure regulation through circadian variation: PRDM16 as a target in vascular smooth muscle cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 39895629.
- Also identified by DOI 10.1172/JCI188784 and PMC identifier 11785916.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The precise mechanisms of blood pressure (BP) regulation are not fully elucidated, and understanding BP regulation is crucial for managing hypertension and improving outcomes for cardiovascular disease. In this issue of the JCI, Wang et al. identified the transcription factor PR domain-containing protein 16 (PRDM16) as a regulator of both vascular smooth muscle cell contraction and the circadian response to BP control. PRDM16 directly transcriptionally controlled the expression of the adrenergic receptor α 1d and several clock genes crucial for BP circadian regulation. These findings identify a mechanism of how molecular pathways govern circadian BP variation, highlighting PRDM16 as a potential target for hypertension.
Medical subject headings
- Muscle, Smooth, Vascular
- Circadian Rhythm
- Transcription Factors
- Blood Pressure
- DNA-Binding Proteins
- Myocytes, Smooth Muscle