HMGA1 is a crucial mediator of colon tumorigenesis driven by the loss of APC.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39895631.
- Also identified by DOI 10.1172/JCI187442 and PMC identifier 11785912.
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Abstract
Colorectal cancer is the second leading cause of cancer death in the United States. The adenomatous polyposis coli (APC) pathway plays a critical role in colorectal tumorigenesis, but the mechanism is not fully understood. In this issue of the JCI, Luo and colleagues used genetically engineered mouse models to show that high mobility group A (HMGA1) is a critical mediator in the development of colon tumors driven by the loss of the Apc gene. HMGA1 activated the transcription of Achaete-Scute Family BHLH Transcription Factor 2 (ASCL2), which regulated intestinal stemness and promoted colon tumorigenesis.
Medical subject headings
- HMGA1a Protein
- Colonic Neoplasms
- Adenomatous Polyposis Coli Protein
- Carcinogenesis
- Genes, APC