2024 Anal Cancer Screening Guidelines: Analysis of Clinical Performance and Use of High-Resolution Anoscopy in a Large Cohort of Persons With HIV.

Gaisa, Michael; Deshmukh, Ashish; Sigel, Keith; Liu, Yuxin · Clin Infect Dis · 2025

prospective_cohort · Level II

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Abstract

Recently published anal cancer screening guidelines recommend 5 strategies for high-risk populations using combinations of cytology and high-risk human papillomavirus testing. Based on data from 1223 persons with human immunodeficiency virus, all triage and cotesting strategies outperformed cytology alone. High-risk human papillomavirus testing improved specificity and reduced high-resolution anoscopy referrals, essential for guideline implementation.

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